Uvod v področje: oblike celične smrti: nekroza in programirana nekroza, apoptoza, avtofagija.
Apoptoza: osnovne značilnosti apoptoze, molekularni mehanizmi regulacije, biološki pomen apoptoze.
Avtofagija: molekularni mehanizmi, regulacija, biološki pomen.
Nekroza/nekroptoza: molekularni mehanizmi, biološki pomen.
Vnetje in piroptoza: splošni mehanizmi, nastanek inflamasoma, medvrstne razlike…
Povezave med različnimi oblikami celične smrti: molekularni mehanizmi, pomen in vloga organelov.
Vloga proteaz pri regulaciji celične smrti: pomen proteaz za celično smrt oziroma preživetje celic.
Programirana celična smrt pri boleznih: nevrodegenerativna obolenja, rak, HIV, ishemija, virusne okužbe, parazitska obolenja, infektivne bolezni.
Analitske metode spremljanja celične smrti: encimatske metode, mikroskopija, imunološke metode, pretočna citometrija, itd.
Klinični razvoj: rak (IAP, Bcl-2 antagonisti, regulatorji autofagije, kemoterapija,…), neurodegenerativne bolezni.
Introduction to the field: cell death types; apoptosis, necrosis and programmed necrosis, autophagy.
Apoptosis: basic characteristics of apoptosis, molecular mechanism of regulation, biological relevance.
Autophagy: molecular mechanisms, regulation, biological relevance.
Necrosis/necroptosis: molecular mechanisms, biological relevance.
Inflammation and pyroptosis: basic mechanisms, inflammasome formation, species difference…
Links between different types of cell death: molecular mechanisms, organelle crosstalk.
Role of proteases in cell death regulation: importance of proteases for cell death or cell survival.
Programmed cell death in disease: neurodegeneration, cancer, HIV, ischemia, viral infections, parasitic diseases, infectious diseases.
Analytical methods for monitoring cell death: enzymatic methods, microscopy, immunological methods, flow cytommetry…
Clinical development: cancer (IAP, Bcl-2 antagonists, autophagy regulators, chemotherapy,…), neurodegenerative disorders.